Synthesis, characterization and biological evaluation of indole-2-carboxamides fused with imidazolinone moiety

[摘要] A novel series of indole-2-carboxamides fused with imidazolinone derivatives were synthesized from 1H-indole-2- carbohydrazide and different 4-arylidene-2-phenyl-5-oxazolinones in pyridine. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for their antibacterial and antifungal activity (MIC) in vitro by broth dilution method with two Gram-positive bacteria, two Gram-negative bacteria and two fungal strains. The biological activities of the synthesized compounds have been compared with standard drugs Ampicillin and Greseofulvin. The compounds exhibited significant antibacterial and moderate antifungal activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the antimicrobial screening of the new compounds are reported.

[学科分类] 药理学