Formulation and evaluation of medicated chewing gum of Ondancetron HClfor chemotherapy induced nausea and vomiting

[摘要] Medicated chewing gum is an excellent drug delivery system for self medication as it is convenient and can be administered discreetly without water. They can be used for the treatment of mouth diseases or systemic absorption through oral mucosa. Medicated chewing gum contains masticatory gum base along with pharmacologically active ingredient which is intended to chew not to be swallowed. Available data suggest that the world market for chewing gum is approximately 560,000 tons, which represents approximately US $5 billion annually. One piece of chewing gum weighs, on average, 1.5 g, and some 374 billion pieces are sold worldwide every year. Medicated chewing gums were prepared by Compression method .PVP, PVA, beeswax, dextrose, calcium carbonate, peppermint, ascorbic acid, Polyethylene glycol 400 and Ondancetron Hcl were used in the formulation in different concentration .Formulations were subjected for following evaluation Weight variation , Friability , Texture analysis & In vitro dissolution studies. Best promising formulation was selected and it was found to be formulation batch FR4 which showed gumminess 8126.33, chewiness 6144.29 and resilience 0.725 among all prepared formulation.

[学科分类] 药理学