Design and evaluation of levofloxacin floating tablet

[摘要] The floating drug delivery systems are designed to retain in the stomach or gastric residence for prolonged and predictable period of time. It is helpful for enhance the bioavailability and reduces the fluctuations of the drug concentration also to achieve the controlled plasma level. In the present investigation, the floating dosage form contains levofloxacin as a main drug. The drug levofloxacin is first choice drug used for treatment of Helicobacter Pylori. These tablets or formulations contains drug, HPMC, Chitosan, Carbopol and some other additives were compressed by using wet granulation method. Tablets are evaluated for hardness, uniformity of weight, drug content friability, swelling index. All the readings are within standard limits and besides optimal floating lag time less than 30 sec. and total floating time less than 15 hrs. FTIR studies shows there is no interaction with the additives. In vitro release study was carried out by using 0.1N Hcl, at different time intervals like 2, 4, 6, 8, 10, 12 and 14hrs.

[学科分类] 药理学