Formulation and evaluation of diclofenac sodium oro dispersible tablets usingdifferent superdisintegrants by direct compression technique.

[摘要] Aim of the present work was to formulate a tablet which disintegrates and dissolves rapidly to show a rapid onset of action. Diclofenac sodium, a non steroidal anti inflammatory drug with analgesic and anti inflammatory properties was selected as a model drug. In the present study, attempt has been made to prepare fast dissolving tablets of diclofenac sodium using 3 different superdisintegrants like Sodium starch glycolate, croscarmellose sodium, and cros povidone by direct compression technique using 3 different concentrations of each superdisintegrant. The pre compression parameters of the prepared tablet blend like angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio and the post compression parameters of the tablet like hardness, friability, weight variation, in vitro dispersion time, wetting time, water absorption ratio, in vitro disintegration time and in vitro drug dissolution were evaluated. It was concluded that formulation F10 showed better release characteristics of the drug.

[学科分类] 药理学