Hepatoprotective activity of methanolic extract of Ecbolium viride (Forssk.)alston roots against paracetamol induced hepatotoxicity

[摘要] In the present study, hepatoprotective activity of methanolic extract of Ecbolium viride (Forssk.) Alston roots in paracetamol induced hepatotoxicity were investigated. The activity was assessed against paracetamol induced hepatotoxicity by measuring the levels of serum enzymes like SGOT SGPT and ALP, total proteins, total bilirubin, and triglycerides. Further, hepatic tissues were also subjected to histopathological studies. The extract showed significant hepatoprotective activity at 200 mg and 400 mg/kg b.w by decreasing the levels of SGPT, SGOT, ALP, total bilirubin, triglycerides and increasing the level of total proteins when compared to toxicant group. The histopathological studies further supported the activity. The results of the present study proved the hepatoprotective potential of methanolic extract of Ecbolium viride (Forssk.) Alston

[学科分类] 药理学