Formulation and optimization of Mucoadhesive Galantamine Loaded Nanoparticles

[摘要] Optimization is used in formulation design to make process fabrication as perfect and effective as possible. Optimization is needed to explore and define ranges for formulation and processing parameters to produce ‘the best fit model’ under a given set of restrictions. Nanopaticulate formulations were designed and developed for anti Alzheimer’s drug galantamine hydrobromide. Chitosan and thiolated chitosan were used for fabrication of nanoparticles by ionic gelation method with tripolyphosphate (TPP) as cross-linking agent. The influence of various factors i.e. Polymer concentration, cross linking agent concentration and stirrer speed were investigated by Box- Behnken Design for optimization. Effect of the selected factors were studied on the responses measured i.e. Particle size, drug entrapment efficiency and mucoadhesive potential.

[学科分类] 药理学