Effects of Pistacia vera methanolic extract against Leishmania major promastigotes

[摘要] Here, we evaluated the in vitro leishmanicidal effects of Pistacia vera methanolic extract against Leishmania major promastigotes. The leishmanicidal effects of extract on L. major promastigotes were performed using MTT method. The values of IC50 were determined using SPSS software. The findings indicated that P. vera methanolic was significantly inhibited promastigote of L. major based on a concentration and time dependent form. The measured IC50 values for extract and glucantime were 31.15 μg/mL and 44.6 μg/mL, respectively. The findings indicated leishmanicidal activity of P. vera methanolic on L. major promastigotes. However, further studies will be required to approve these results by checking in the animal models as well as volunteer human.

[学科分类] 药理学