Anti-diabetic activity of Cassia auriculata flowers in α- amylase inhibition andglucose uptake by isolated rat hemi-diaphragm

[摘要] Diabetes mellitus (DM) has a profound adverse effect on quality of life in terms of social, psychological well-being as well as physical health. Diabetic complications are mainly mediated through oxidative stress such as increased production of Reactive Oxygen Species (ROS) or impaired antioxidant defence system. Enhancement of lipid peroxidation, alteration in antioxidant enzymes and impaired glutathione metabolism are the main factors involved in the development of diabetes. Production of free radicals is also involved in the pathogenesis of various type of disease including diabetes mellitus. Increased formation and accumulation of advanced glycation products elimination (AGEs) is also involved in the diabetic complications, such as retinopathy, neuropathy, nephropathy and renal dysfunction through a series of pathological changes. the aim present study was evaluate In vitro Anti-diabetic activity of Cassia Auriculata flowers and its phytochemical studies done by In vitro α- Amylase Inhibition Assay and In vitro Glucose Uptake by Isolated Rat Hemi-Diaphragm.

[学科分类] 药理学