A comparative study on the angiogenic effects of Artocarpus heterophyllusLam. (Langka) and Artocarpus odoratissimus Blanco (Marang) crude leafextracts on chorioallantoic membrane (CAM) of 12-day old duck embryo

[摘要] The study tested the crude leaf extracts of two plant species under Family Moraceae in 12-day old duck embryo for angiogenic activity using chorioallantoic membrane (CAM) assay. Approximately 300 g of fresh leaves of Artocarpus heterophyllus Lam.(jackfruit) and Artocarpus odoratissimus Blanco(marang) were collected and extracted using 95% ethanol and rotary evaporator. Three concentrations,100ppm, 200ppm, and 300ppm, for each of the leaf extract were prepared and administered on the test eggs. After another 48 hours of incubation, the CAM of test eggs were harvested and collaterals were counted. Results showed that both plant extracts showed antiangiogenic activity indicated by the decrease in the number of collaterals. In the two plant samples, 300ppm of A. odoratissimus exhibited the highest inhibitory effect; this could be attributed to the presence of phenolic compounds, such as flavonoids, saponins, glycosides, sterols, tannins and anthocyanins.

[学科分类] 药理学