Anti-inflammatory evaluation of isoxazole derivatives

[摘要] A new series of isoxazole derivatives were synthesized by synthesizing various chalcone derivatives and cyclizing them to give resultant isoxazole derivatives (TPI1- TPI20).. All the synthesized derivatives were characterized with FTIR and NMR spectral analysis and evaluated for their anti-inflammatory activity in vivo (carrageenan induced paw ooedema method in rats). The isoxazole derivatives TPI-7 and TPI-13 were found to be the most active compounds due to the presence of the methoxy group at para position.. In future study, further investigation on the mechanism of action of some of our compound may reveal new compounds with potent anti-inflammatory action. The structures of the newly synthesized compounds were elucidated by using IR, 1H NMR.

[学科分类] 药理学