Isolation and characterization of a constituent from the leaves of Kalanchoecrenata and its evaluation for antioxidant activity

[摘要] Kalanchoe crenata (Adrews) Haw. is an ornamental plant belonging to the family Crassulaceae is probably native to Africa and drier parts of south-east Asia. Commonly known as “never die” or “Dog’s liver”, this plant is widely used in traditional medicine in the treatment of inflammation, earache, headache, asthma, palpitation, abdominal pain, convulsion and general debility [1]. The leaves of K.crenata possess analgesic, anticonvulsant & spasmolytic properties [2, 3, 4].The present research includes isolation and characterization of chemical constituent and in vitro evaluation of antioxidant potentials by assay method of isolated constituent from leaves of Kalanchoe crenata. Chemical constituent (hentriacontan-1-ol) was isolated and the structures of this compound have been established by spectroscopic methods (UV, 1H-NMR, IR, MS). This constituent was isolated from this plant for the first time. This chemical constituent showed significant antioxidant activity in dose dependent manner assay method. The result obtained in the present study indicates that leaves of Kalanchoe crenata could be a potential source of natural antioxidant. This also justified the traditional use of herb in preventing disease induced by oxidative stress.

[学科分类] 药理学