Endothelium-Dependent and -Independent Vasodilation in Young Males with Previous Myocardial Infarction

[摘要] Flow-mediated vasodilation - a non-invasively measurable index of endothelial function - is a good predictor of cardiovascular risk. This study was undertaken to analyse the correlation between flow-mediated vasodilation and the severity of coronary artery disease in males less than 40 years of age and with myocardial infarction in their history. Coronary angiography demonstrated single-vessel disease in 16 patients (Group A) and multi-vessel disease in 12 (Group B). The control group comprised 14 healthy young males (Group C). Endothelium-dependent vasodilation produced by reactive hyperaemia, as well as nitroglycerine-induced, endothelium-independent vasodilation was appraised on the brachial artery, using a high-resolution duplex ultrasound device (ACUSON 128XP/10). Variations in vessel size recorded as prescribed by the protocol developed by Celermayer were expressed as percentage change compared to baseline.Compared to controls, endothelium-dependent vasodilation was attenuated in patients with previous myocardial infarction (p < 0.01). The same applies to multi-vessel disease, in comparison to single-vessel disease. There was no difference between controls and postinfarction patients as regards nitroglycerine-induced vasodilation.Endothelium-dependent vasodilation is diminished in young males with previous myocardial infarction, and the magnitude of this reduction is related to the severity of coronary artery disease.

[学科分类] 心脏病和心血管学

[关键词] Endothel;Kardiologie;Mann;Myokardinfarkt;Vasodilatation;cardiology;endothelium;Male;myocardial infarction;Vasodilatation