Distribution of CCND1 A870G Polymorphism in Patients with Advanced Uterine Cervical Carcinoma

[摘要] We examined the distribution of the CCND1 A870G (rs9344) polymorphic variant in patients with cervical cancer (n�?=�?129) and healthy individuals (n�?=�?288) in a sample of a Polish cohort. We showed that patients with advanced cervical cancer bearing the CCND1 A/A and A/G genotypes displayed a 1.811-fold increased risk of cervical cancer (95% CI�?=�?1.150�?2.852, p�?=�?0.0098). We also found a significantly higher frequency of the CCND1 870A allele in patients with cancer than in controls, p�?=�?0.0116. Our investigation confirmed that the CCND1 870A gene variant may be a genetic risk factor in the incidence of advanced cervical cancer.

[学科分类] 生理学与病理学

[关键词] Polymorphism