Tumor Necrosis Factor Alpha (�?238 / �?308) and TNFRII-VNTR (�?322) Polymorphisms as Genetic Biomarkers of Susceptibility to Develop Cervical Cancer Among Tunisians

[摘要] Host genetic factors may confer susceptibility to Cervical Cancer. TNF-α as pro-inflammatory cytokine participates in the maintenance of immune homeostasis. Allelic variation of immuno-modulatory genes is associated with alteration in immune function. This study investigated the associations between TNF-α-308G>A, �?238G>A, and TNFRII - VNTR-322 and cervical cancer in Tunisian women. Genotypes of those polymorphisms were detected in 130 cases and 260 controls. The variant heterozygote �?308 G/A was associated with a 41 % decreased risk of cervical cancer (GG vs A/A; p�?=�?0.002; OR = 0.41; 95 % CI =0.23�?0.76). Furthermore, compared with dominant variant G/G, the (G/A+A/A) genotypes was significantly associated with a decreased risk of CC (GG vs G/A+A/A; p�?=�?0.026; OR = 0.62; 95 % CI = 0.40�?0.97). The FIGO stratified analysis showed that the minor variant A/A and combined G/A+A/A of TNFα-238 G>A and TNFα-308 G>A increased the risk of the tumor evolution, respectively, (P�?=�?0.011; OR = 2.98; 95 % CI = 1.16�?7.72) (P�?=�?0.008; OR = 2.76; 95 % CI = 1.20�?6.41), (P�?=�?0.000; OR = 16.33; 95 % CI = (5.10�?55.23) (P�?=�?0.000; OR = 7.54; 95 % CI = 2.68�?22.29). There was statistically significant relationship between the incidence of the TNF-α mutations and the clinical progression of cancer according to the FIGO classification. In our study, the haploview analysis revealed no LD between rs1800629 and rs361525. TNF-α and TNFRII polymorphisms might be genetic risk factors for cervical cancer inTunisian population

[学科分类] 生理学与病理学

[关键词] Haplotypes