A Meta-Analysis of HIF-1α and Esophageal Squamous Cell Carcinoma (ESCC) Risk

[摘要] To investigate the correlation of hypoxia-inducible factor-1α (HIF-1α) expression with clinical prognosis and efficacy of radiochemotherapy in esophageal squamous cell carcinoma (ESCC). Studies assessing the clinical or prognostic significance of HIF-1α expression in ESCC published prior to December 2011 were selected by searching PubMed, EMBASE, Cochrane Library, and (China National Knowledge Infrastructure) CNKI. A meta-analysis was performed to clarify the impact of HIF-1α expression on clinicopathological parameters or survival in ESCC. A total of 16 studies met the inclusion criteria, which included 1261 patients with ESCC. Accordingly, the level of HIF-1α expression in esophageal tissues of patients with ESCC was significantly higher than that in normal patients (odds ratio, OR�?=�?33.111, 95 % confidence interval, CI�?=�?11.912�?92.040). The expression of HIF-1α correlated with the depth of invasion (OR�?=�?1.701, 95 % CI�?=�?1.076�?4.705), clinical TNM stage (OR�?=�?2.160, 95%CI�?=�?1.516�?3.077), as well as lymph node metastasis (OR�?=�?2.393, 95 % CI�?=�?1.319�?4.344), regardless of differentiation grading (OR�?=�?1.185, 95 % CI�?=�?0.859�?1.635). Furthermore, there was a significant association of increased HIF-1α expression with poorer radiochemotherapy outcomes, 2-year overall survival (OR�?=�?0.219, 95 % CI�?=�?0.104�?0.461) and survival (OR�?=�?0.320, 95 % CI�?=�?0.115�?0.887, P�?<�?0.05) in patients with ESCC. In addition, HIF-1α expression correlated with VEGF expression in the ESCCs (OR�?=�?4.635, 95%CI�?=�?2.591�?8.292). Increased expression of HIF-1α plays an important role in the malignant biology of ESCC resulting in significantly poorer radiochemotherapy outcomes and 2-year overall survival. HIF-1α expression may be a prognostic factor, as well as a potential target for therapy in patients with ESCC.

[学科分类] 生理学与病理学

[关键词] Survival