Retrospective evaluation of 5-fluorouracil-interferon-α treatment of advanced colorectal cancer patients

[摘要] The authors describe the retrospective analysis of treatment by 5-fluorouracil and interferon-α of 34 patients with advanced colorectal cancer. An average of 4.6 treatment cycles (3�?12) was applied. Complete remission was not observed; partial remission was observed in 8 patients; in 13 patients no change occurred and progression was detected in 14 cases. Remission rate was 22.8%, mean response time was 5.2 (3�?12) months, mean progress-free survival 5.6 (0�?22) months. Mean survival from the start of treatment was 11.9 (1�?42) months and from the establishment of the diagnosis 26.1 (3�?60) months. Severe life-threatening side-effects did not occur; other side-effects such as fever, nausea, diarrhea, leucopenia, and anemia responded to drugs. Treatment by 5-FU and interferon, in accordance with other authors�? findings, improved survival and well-being of patients but no breakthrough has been achieved.

[学科分类] 生理学与病理学

[关键词] survival