Neurotoxicity of acrylonitrile evaluated by manganese enhanced magnetic resonance imaging

[摘要] Acrylonitrile (ACN), a chemical compound commonly used to manufacture plastics, has been found in drin king water and as a pollutant in the air. Exposure to high levels of ACN leads to brain lesions via oxidative stress-induced injury. To date, there is no non-invasive method of examining brain lesions. We determined if manganese-enhanced magnetic resonance imaging (MEMRI) can be used to detect brain lesions in ACN-treated rats by exploiting the binding properties of manganese to the enzymes manganesesuperoxide dismutase (Mn-SOD) and glutamine synthetase (GS). Rats exposed to low, mid, and high doses of ACN over 7 days were subjected to MEMRI on the eighth day. Contrast enhancement of the brain decreased in ACN-treated rats, along with marked decreases in Mn-SoD and GS activities, particularly in mid- and high-ACN treated rats. Our study indicates that MEM-RI may be a potential non-invasive method of detecting ACN-induced oxidative damage.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] Manganeseenhanced magnetic resonance imaging