Coix seed extract attenuates the high-fat induced mouse obesity via PPARγ and C/EBPα a downregulation

[摘要] The seed of the Coix lacryma-jobi L. var. ma-yuen Stapf seed (CLMS) extract has been prescribed to alleviate obesity by practitioners of traditional Korean medicine. Here, we investigated the effect of CLMS extract on PPARγ² and c/EBPα and obesity responses in C57BL/6J obese mice fed on a high fat diet. The mouse body index, blood profile, and fat accumulation levels in the liver were measured. The protein expression levels of PPARγ² and c/EBPα in the mice livers were also measured to determine the molecular mode-of-action of the reducing effect of CLMS extract on mouse adipogenesis. The results showed that HFD-induced mouse obesity, fat accumulation, and serum cholesterol were alleviated by the CLMS extract addition. Moreover, PPARγ² and C/EBPα, proteins, those are related to the adipogenesis, were downregulated by the CLMS extract intake considerably. This study indicates that as a food additive, CLMS extract has a reducing effect on the high-fat diet induced fat accumulation and on body weight through the downregulation of adipogenesis.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] PPARα2