(-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid presents antitumor activity in HT-29 human colon cancer in vitro and in vivo

[摘要] (-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl) quinic acid (GQA), new compound isolated from Lonicera japonica, was found with the activity of inhibiting HIF-1. GQA exhibited anti-proliferative effects on a broad spectrum of tumor cell lines in HIF-1 dependent mechanism and could induce HT-29 cell apoptosis through the mitochondrial pathway. Oral administration of GQA showed significant inhibition against tumor growth of human colon carcinoma xenografted in nude mice. For the first time, this study provides scientific rational to develop GQA as a novel class of antitumor agents against the human colon carcinoma.

[学科分类] 分子生物学，细胞生物学和基因

[关键词] Nude mice