A Study of the Antigenic Activity of Preparations Made from Various Strains of Treponema Pallidum

[摘要] Distilled water, salt solution, and methyl alcohol are satisfactory solvents of the antigenic substances from all strains of Treponema pallidum studied. Extracts of certain strains of ethyl alcohol were of low antigenic activity.Although more marked fixation occurred in the presence of homologous antiserum, there was considerable cross fixation between strains which would suggest that, although the strains vary, they do not differ essentially in antigenic activity.Alcoholic extracts of Kroó and Klopstock strains react in the presence of syphilitic serum, more strongly than similar extracts of the Zinsser and Noguchi strains but always to a much less degree than do routine nonspecific organ extracts. Aqueous or saline extracts show little activity in such systems.From the fact that the relationship between the amount of complement fixed by the alcoholic spirochete extracts and by the routine antigens remained fairly constant, it is assumed that the reaction in both cases is dependent upon the lipoidal character of the preparations.

[学科分类] 生物科学（综合）