Skin Reactions to the Colon Bacillus and Its Toxic Products
[摘要] Normal persons give a positive reaction to intradermal injections of B. coli toxic filtrate and washed organisms. Children show a more marked reaction than adults. Patients with a long standing colon bacillus infection react slightly and a small percentage of the patients do not react at all. Negative reactions to the vaccine are more numerous than to the soluble toxic substance. Immunization with B. coli soluble toxic substance reduces but does not obliterate the reaction. Absence of B. coli agglutinins cannot be used as a criterion for absence of other neutralizing antibodies since the agglutinin titer was either nil or slight in persons with negative reactions.Because normal persons give positive reactions and patients with long standing colon bacillus infection show negative or reduced reactions, the phenomenon is assumed by us to be one in which antibodies neutralize the colon bacillus toxic substances, both soluble and that derived from the bacterial bodies. Our work thus far does not justify either an acceptance or a refutation that thephenomenon may be of an allergic nature as suggested by some workers. It is further concluded that under the conditions of these experiments, the skin reaction for the determination of the presence of colon bacillus infection is of uncertain value.
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[效力级别] [学科分类] 生物科学(综合)
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