Natural Agglutinins and Their Relationship to the Somatic and Flagellar Antigens of Bacteria

[摘要] 1. 1. Normal serum from various mammalian animals contains agglutinins which react with the “H” and “O” antigenic constituents of many bacteria. Flagellar suspensions have been used to demonstrate H-agglutinins.2. 2. Agglutinin-absorption experiments show that the specificity of natural agglutinins (as described in a previous communication) depends chiefly on the “H” type. The “O” type agglutinins appear to possess affinities for antigenic constituents which are more widely shared by different organisms.3. 3. It was not found possible to demonstrate the antigenic relationship among members of the Salmonella and B. proteus X groups so precisely with normal sera as with immune sera.4. 4. the thermolability of the O-agglutinins was found to be greater than that of the “H” type in the normal serum of a number of animal species. Both showed greater lability than the corresponding immune agglutinins.5. 5. “Rough” and “smooth” variants of the same bacterial strain showed antigenic differences in their reactions with normal sera.

[学科分类] 生物科学（综合）