The Agglutinin Response to Typhoid-Paratyphoid Vaccination

[摘要] Recent claims that prophylactic vaccination against typhoid and paratyphoid fever is not effective because of the absence of somatic antibodies in the sera of vaccinated persons have not been substantiated; somatic antibodies could be detected with proper reagents after administration of a proper vaccine. A vaccine which failed to prevent small outbreaks of typhoid and paratyphoid B infection in a state hospital was found to be deficient in production of somatic agglutinins and its bacterial count was far below specifications. A convenient detector of H agglutination, namely chloroform-treated bacilli, is described.

[学科分类] 生物科学（综合）