Phenomenon of Local Skin Reactivity to Meningococcus: Production of Neutralizing Antibodies in Horses

[摘要] Titrations of neutralizing antibodies of antimeningococcus horse sera with the aid of the auxiliary antibody disclosed wide fluctuations in their concentration during the immunization. A description is given of a simple and economical method of immunization which shows high titer of neutralizing antibodies for the phenomenon of local skin reactivity.Incidental observations reported are those on full antigenicity of meningococcus toxic filtrates, and also on the fact that the neutralizing antibodies may fluctuate in their concentration, while the agglutination and precipitation titers remain stationary.The author wishes to express his gratitude to Mr. Arno Koovits for his capable technical assistance.

[学科分类] 生物科学（综合）