Role of Host Defenses in Systemic Klebsiella Pneumoniae Infection: Effect of Antibiotics in Normal and X-Irradiated Mice

[摘要] No bacteremia was observed in adult albino Mus musculus for 10 days following exposure to 350 r (LD0/30 days) of total body irradiation. The natural resistance of such irradiated mice to intraperitoneally induced Klebsiella pneumoniae infection was significantly depressed on the first, second, fourth and ninth post-irradiation days when the animals were challenged. The significance of host defense participation in recovery from the experimental infection was inferred from the greater mortality among irradiated and treated mice than among non-irradiated and treated control animals. The critical significance of the cellular defense mechanisms of the albino mouse has been discussed.

[学科分类] 生物科学（综合）