Prevention of Virus Interference by 2,5-Dimethylbenzimidazole

[摘要] 1. 1. Interference among homologous and heterologous strains of influenza A and B viruses has been demonstrated in chorioallantoic membrane cultures in vitro .2. 2. The preparation of inactivated influenza A or B viruses for interference experiments by heating at low temperatures (22° or 37°C) preserved more of the interfering activity of the untreated virus than heating at 56°C, although infectivity was effectively eliminated in all instances.3. 3. 2,5-Dimethylbenzimidazole, at a concentration of 2.6 × 10-3 M, prevented, to a varying extent, the induction of interference by inactivated influenza A (WS strain) or influenza B (Lee strain). Holding membrane cultures at 4°C in the absence of the compound had a similar effect.

[学科分类] 生物科学（综合）