Virus Proliferation in the Mouse

[摘要] Growth curves were constructed for the proliferation of influenza virus (mouse-adapted PR 8) in the mouse lung and mouse encephalomyelitis virus (Theiler's GD VII) in the mouse brain. The data obtained in these experiments indicate: 1) both viruses demonstrate cyclic development, 2) maximal infection occurs earlier with influenza virus than with TheileR′s GD VII, 3) the latent period, following inoculation for influenza virus, is approximately 1–3 hours, depending upon the size of inoculum. When very small inocula are employed, no virus may be detected during this latent period. An increase in amount of virus occurs and is followed by a leveling off of virus content for a period of approximately 6 hours. Again, there is another incremental period of about 3 hours and another plateau may be observed, which continues if maximal infection has occurred; 4) this pattern of proliferation is also observed with the GD VII virus except that the time intervals described for influenza virus are lengthened. Following the initial drop in titer after inoculation, there is a marked decrease in detectable virus followed by a latent period of approximately 3–6 hours. Cyclic periods of proliferation occur at approximately 6-hour intervals. From the above data and from reports on other viruses, it would appear that viruses, in general, proliferate within their host's tissues in a cyclic fashion.

[学科分类] 生物科学（综合）