Studies with Influenza Virus B of Recent Human Origin

[摘要] Genetic interaction was demonstrated between a mouse-unadapted influenza B virus, Rob, of recent human origin, which produces extensive pulmonary consolidation and multiplication of virus only upon initial inoculation into the mouse lung, and the Mil strain of influenza B virus. Interaction was also found to occur between Mil and mouse-adapted Rob viruses. An analysis of the distribution of mouse lung virulence among the progeny has indicated that multiple genetic factors are involved in both “crosses.” Back-recombination to give the original strains was obtained with “recombinants” isolated from the experiment involving Mil and unadapted Rob viruses.The results indicate that the initial effects of pulmonary consolidation and multiplication in the mouse lung by an unadapted influenza B virus may be controlled by genetic mechanisms.

[学科分类] 生物科学（综合）