The Biologic Role of Host Antigens in Newcastle Disease Virus

[摘要] An immunologic phenomenon is described: induction of susceptibility of mice to infection by chicken embryo-adapted NDV in animals rendered “tolerant” to chicken embryo antigens. “Tolerant” mice developed pulmonary lesions and viremia after intranasal inoculation of NDV and the virus could subsequently be maintained in mice by direct passage. Susceptibility to the virus was not induced in animals injected as newborns with heterologous antigens.

[学科分类] 生物科学（综合）