Regulation of Cellular Antibody Synthesis

[摘要] Adoptive transfer of spleen cells from hyperimmunized or primarily immunized donors into normal syngeneic recipients caused an efficient suppression of cellular 19 S synthesis against sheep red blood cells subsequent to antigenic stimulation, as compared to the response in mice given antigen only. Thus, endogenously produced antibodies may play a regulatory role also in the primary immune response and act to terminate 19 S synthesis. However, the same recipients exhibited a marked stimulation of 7 S synthesis at the cellular and humoral level as well. It was concluded that the phenomenon of antibody suppression functions in a feedback system to terminate 19 S synthesis in the primary and secondary response. In addition, the same phenomenon permits the selective stimulation of such antigen-sensitive cells that can compete efficiently for antigen with the serum antibodies.

[学科分类] 生物科学（综合）