Complementarity of Heavy and Light Chains from Antibodies of the Same Specificity Derived from Different Rabbits

[摘要] The specific activity of heavy chains derived from anti-DNP antibody of an individual rabbit was in general enhanced upon combination with light chains of the same specificity from a different rabbit. The activities of such recombinants could not be accounted for on the basis of additivity of binding capacities of the individual chains. This indicates that there are structural similarities, related to specificity, among the light chains of anti-DNP antibodies synthesized in different animals. In agreement with previous work, maximal activity of recombinants was observed when the chains were derived from the same animals.

[学科分类] 生物科学（综合）