Immunologic Incompetence of Mouse Perinatal Liver Hematopoietic Cells against Transplantation Antigens

[摘要] Liver hematopoietic cells were collected from fetal and neonatal C57BL/6 mice at eight equidistant points in time beginning on the 13th day of fetal life and ending on the 7th day after birth. Aliquots of these cells were administered intraperitoneally to B6D2F1 mice. The host mice were studied by means of the Simonsen graft- vs. -host spleen weight-gain assay to determine at what stage of fetal or neonatal life mouse liver hematopoietic cells first acquire immunologic competence against transplantation antigens. None of the mouse liver hematopoietic cells from fetal or neonatal parental strain mice demonstrated immunologic reactivity against transplantation antigens in their F1 hybrids with the doses employed and as measured by this assay system.

[学科分类] 生物科学（综合）