Abstracts of Papers Presented at the Third International Complement Workshop, Harvard Medical School, Boston, Massachusetts, June 3–5, 1968

[摘要] Evidence has been obtained for the existence of functionally different C′4 molecules. Their existence was deduced from studies of the influence of temperature and immunoglobulin class on the generation of SAC′14 and of the interaction of attached C′4 with anti-C′4 antibodies. Four different kinds of sites have been identified: (1) Competent (hemolytic) sites generated with IgM or with IgG antibodies. The generation of these sites is favored by low temperature. (2) Incompetent (non-hemolytic) sites generated with IgM or with IgG antibodies that are capable of reaction with and activation of C′2. The generation of these sites is favored by elevated temperature. (3) Potentially competent hemolytic sites generated with IgG antibodies that can be converted to hemolytic sites by IgM antibodies. (4) Sites that are neither hemolytic nor capable of using up C′2 and cannot be converted to hemolytic sites. These sites were detected by their ability to react with anti-C′4 antibodies. Elevated temperature favors generation of these sites.

[学科分类] 生物科学（综合）