Serum Complement in the Rejection of Sarcoma I Ascites Tumor Grafts

[摘要] The reactivity of sarcoma I, isoantibody, and complement (C′) was studied in vitro and in vivo . C′ activity was needed in the cytotoxic reaction in vitro . When inoculated into the peritoneal cavity of presensitized mice, tumor cells bound mouse γ-globulin and C′ (β1C protein) within 2 min. Tumor growth resulted in decreasing serum C′ titers. There was a positive relation between the number of tumor cells implanted, loss of C′ activity and death of the recipient animals. B10D2/new line mice which possess a lytic C′ system were at least 10 times more efficient in the destruction of tumor implants than B10D2/old line mice which lack C′5 activity.It is concluded that C′ participates in the rejection reaction against allografted sarcoma I tumor and that biologic functions dependent on the activity of C′5 are preeminent in the graft destruction. A second mechanism was independent of C′5 and less efficient.

[学科分类] 生物科学（综合）