Antigenic Variants of Arboviruses

[摘要] Seven antigenically distinct subpopulations of virus were recognized among 32 viral clones recovered after plating various chick embryo tissue culture passage levels of the parent Arg-B strain of EE virus. Each of the distinct clones was antigenically stable for at least seven passages in a single type of susceptible host. Virus populations from clones which were antigenically identical when grown in one host remained identical after propagation in other hosts. However, when one type of viral clone was propagated in different hosts, the antigenic properties of progeny virus from each host type were distinctly different. There appeared to be some relationship between the persistence of different clone types, the antigenic nature of cloned viruses and their rates of replication in tissue culture.

[学科分类] 生物科学（综合）