Serum Factors and the Reticuloendothelial Uptake of Staphylococcus Aureus

[摘要] Utilizing isolated perfused rabbit livers and rabbit serum, the following conclusions were made concerning the serum requirements for hepatic removal of both wild type and encapsulated staphylococci: 1. 1. Normal serum enhanced the hepatic removal of both wild type and encapsulated staphylococci.2. 2. Both heat stable and heat labile serum factors were involved in this enhancement.3. 3. The heat stable factor could be partially removed from normal serum by absorption with both wild type and encapsulated strains of Staphylococcus aureus but not by a coagulase-negative strain.4. 4. As in phagocytic systems utilizing polymorphonuclear leukocytes, the encapsulated staphylococci appeared more resistant to phagocytosis and their hepatic removal was greatly enhanced by specific immune serum.5. 5. Serum from animals immunized with wild type staphylococci consistently improved hepatic removal of wild type strains over that observed with normal serum only when heat labile factors were absent from such sera.6. 6. The reticuloendothelial removal of staphylococci and the phagocytosis of staphylococci by polymorphonuclear leukocytes both appear to be serum-dependent host defense mechanisms.

[学科分类] 生物科学（综合）