Studies on Mechanisms of Immunity in Listeriosis

[摘要] 1. 1. The interaction of peritoneal exudate cells of sheep with Listeria monocytogenes was studied in vitro in Kapral-type cell culture chambers. Four combinations of reactants were studied: immune cells + immune serum, immune cells + normal serum, normal cells + immune serum and normal cells + normal serum.2. 2. Immune cells in immune serum resisted the destructive results of the parasitic interaction when compared with the other host cell systems. Samples taken at the 20th hr indicated that the exudate cell counts in the immune cell + immune serum chambers were 39% of the original, whereas the counts in the other systems had declined to less than 5% of their original values.3. 3. Bacterial growth was suppressed in the immune cell + immune serum system. The increase in bacterial growth was greatest in flasks of media containing no host cells. However, bacteria also accumulated rapidly in chambers containing the three other combinations of reactants.4. 4. Parasitic and phagocytic indices were comparable in normal and immune serum.5. 5. Results are discussed regarding a cellular basis of immunity in listeriosis and relationships to other host-parasite studies.

[学科分类] 生物科学（综合）