The Proteins and Antibodies of Serum after Prolonged Dialysis

[摘要] The fractionation by prolonged dialysis of the proteins and antibodies of normal and immune rabbit sera has been investigated.A characteristic serial precipitation occurs when precipitates are removed from the dialyzing bag at intervals. The precipitates change in character, quantity and composition as dialysis progresses. Half or more of the total precipitate is composed of an albumin-like protein.The content of antibody in the serial precipitates roughly parallels their total-nitrogen values. The largest precipitates are also richest in antibody per unit of mass.The antibody-activities displayed by the dialyzed fractions of two of three immune sera indicated that the better-quality antibody of a serum is associated with the water-soluble globulin. Since the “multivalence” of antibody generally increases with progressive immunization, the specific globulin-association of immune body in any particular serum may depend on the immunizing treatment.

[学科分类] 生物科学（综合）