Studies on the Immunization of Adults with Diphtheric Toxoid

[摘要] Various procedures for the immunization of adults with diphtheric toxoid have been advocated in the literature. From these and from our observations on ninety Schick-positive subjects, we have sought an easy regime for routine use. It is not yet clear as to whether Schick-positive, toxoid-sensitive individuals should be left uninoculated. A simple program of intracutaneous injections has rendered twenty-six out of twenty-seven such subjects Schick-negative, leaving only one to undergo a series of graded subcutaneous doses. The plan we have adopted for the whole group is as follows: 1. 1. Do a Schick-test on the group to be immunized.2. 2. Do a Moloney-test on the Schick-positive individuals.3. 3. Give the M neg. and M + reactors the routine 2 ml of undiluted toxoid in 1 ml subcutaneous doses with an interval of one month.4. 4. Give the M ++ and M +++ reactors three 0.1 ml intracutaneous injections of toxoid used for the Moloney-test ( i.e. , a 1:100 dilution of toxoid) at weekly intervals.5. 5. Perform Schick-tests three to six months after the last injection.6. 6. If any M ++ or M +++ subjects remain Schick-positive, inoculate these with a series of graded subcutaneous injections.

[学科分类] 生物科学（综合）