The Proteins and Antibodies of Serum after Prolonged Dialysis

[摘要] When single samples of serum are subjected to prolonged dialysis by both the intermittent and continuous methods, the former is found to result in a greater precipitation of total protein, globulin, and antibody.Sera obtained from a group of animals at successive points in the process of immunization with type 2 pneumococcus give evidence of changing protein- and antibody-relationships. The later sera show a progressively greater increment of water-soluble over total globulin, the presence of relatively larger proportions of total antibody in the water-soluble globulin and this antibody is probably the more multivalent. The evidence in its entirety is considered to support the thesis proposed in previous papers (1, 2); that the first, less avid antibody produced by the rabbit is associated with the water-insoluble globulin, and as immunization proceeds the increasing amounts of multivalent immune body are composed of water-soluble globulin. The specific globulin-association of the antibody produced by this species is thus primarily dependent on the stage during immunization at which serum is obtained.

[学科分类] 生物科学（综合）