Sulfanilamide in Experimental Infections with Streptococci from Scarlet Fever and Erysipelas

[摘要] 1. 1. A technic of sulfanilamide-therapy which was partially effective in protecting white mice against a strain of hemolytic streptococcus specific for erysipelas was ineffective in protecting them against a strain of hemolytic streptococcus specific for scarlet fever.2. 2. No evidence of increased toxicity was found when sterile scarlet fever toxin in 1,000,000 skin-test-dose amounts was administered to mice treated with sulfanilamide.3. 3. The addition of scarlet fever toxin to a culture of erysipelas organisms destroyed the effectiveness of sulfanilamide as a therapeutic agent in protecting white mice against a strain of hemolytic streptococcus specific for erysipelas.4. 4. The effectiveness of sulfanilamide in protecting white mice against the two strains of hemolytic streptococci employed in these experiments was inversely proportional to the amount of toxin which was present in the culture or which was produced by the strain of hemolytic streptococcus used as the infective agent.

[学科分类] 生物科学（综合）