Passive Sensitization of Rabbit's Blood

[摘要] In early studies upon anaphylaxis in rabbits it was reported by Friedemann (1) and by Scott (2) that no latent period was necessary for the passive sensitization of these animals to the subsequent intravenous injection of antigen such as has been shown to be necessary for the guinea-pig and dog. These observations have been rather generally discounted or explained as being anaphylactoid reactions not truly anaphylactic in character. Such an explanation fails to explain why the simultaneous injection of antigen and antiserum does not provoke reactions in either guinea-pigs or dogs with equal facility to that in rabbits and has no bearing at all upon the observations of Opie (3) and others that the Arthus phenomenon can be produced in rabbits by the subcutaneous injection of antigen either before, simultaneously or after the injection of antiserum.

[学科分类] 生物科学（综合）