Antigenic Studies on the Psittacosis-Lymphogranuloma Venereum Group of Viruses

[摘要] The time of onset of cutaneous hypersensitivity in chickens infected with ornithosis virus was related to the LD50 used for infection. Hypersensitivity developed within 4 weeks of infection and was detected for 1 year after infection. Complement-fixation inhibition antibody appeared earlier in the infection than detectable allergy, although after 7 weeks of infection the serological and skin-test methods agreed in approximately 80% of the infected chickens. The skin-test antigen was resistant to periodate, trypsin, desoxyribonuclease, and exposure to 90°C. The complement-fixing and allergenic activities were separated by ultracentrifugal sedimentation of the complement-fixing antigen. The skin-test antigen was standardized on a nitrogen basis in guinea pigs and chickens.

[学科分类] 生物科学（综合）