Purification of Kidney Components Capable of Neutralizing Kidney Localizing Anti-Rat Kidney Antibodies

[摘要] A soluble material capable of inhibiting the localization of kidney localizing anti-kidney antibodies was isolated from a trypsin digest of rat kidney. Further digestion with ribonuclease and desoxyribonuclease removed all phosphorus and nucleic acid components, leaving material whose specific activity was 25 to 50 times that of the original trypsin digest and which contained protein and some carbohydrate.The material can neutralize only about 75% of the kidney localizing antibodies. Therefore, there must be localizing anti-kidney antibodies present in the anti-RK sera which are directed against other antigens than those studied here.

[学科分类] 生物科学（综合）