已收录 272893 条政策
 政策提纲
  • 暂无提纲
The Effect of Streptothricin on Systemic Infection with Cryptococcus Neoformans in Mice
[摘要] The recent advances in the chemotherapy of bacterial diseases have not been accompanied by similar progress in the treatment of fungus infections. The widely used antibiotics, penicillin and streptomycin, are not active against fungi in vitro (1, 2). Furthermore, bacitracin, polymyxin, and chloromycetin which are now being studied for possible application in human therapy, have not been reported to possess activity against fungi that are pathogenic for man. On the other hand, streptothricin, hemipyocyanin, clavacin and gliotixin are effective against pathogenic fungi in vitro (3). The pharmacological properties and antibacterial activity of streptothricin have been investigated thoroughly, but it has not been used for human therapy because of its relatively high toxicity in animals (4, 5).Shortly after Waksman and Woodruff (6) had announced the discovery of streptothricin, Robinson, Smith, and Graessle (2) showed that streptothricin inhibited the growth of Cryptococcus neoformans, Epidermophyton inguinale and Sporotrichum schenkii .
[发布日期]  [发布机构] 
[效力级别]  [学科分类] 生物科学(综合)
[关键词]  [时效性] 
   浏览次数:2      统一登录查看全文      激活码登录查看全文