Model Systems for the Study of Drug Hypersensitivity

[摘要] Anti-aspiryl antibodies were produced in rabbits using three protein carriers. The method of inhibition of precipitation was used to determine the specificity of the antibody produced. ε-Aspiryl-aminocaproate was found to be the most effective inhibitor of those haptens tested, indicating that the combining hapten of the protein is ε-aspiryl-lysyl. Free aspirin and salicylates were poor inhibitors and did not combine with the antibody to a significant extent in equilibrium dialysis experiments. The ortho group in aspiryl and salicylyl amides was found to participate in the binding to antibody. The average binding constants of antibody globulins and specifically purified antibody were measured.

[学科分类] 生物科学（综合）