Autologous Immune Complex Glomerulonephritis

[摘要] Transfer of lymphoid cells from rats with autologous immune complex nephritis induced by intraperitoneal immunization with renal tubular antigen consistently failed to produce disease in normal rats of the same inbred strain. On the contrary, transfer of isologous lymphoid cells from rats with disease induced by intracutaneous and footpad immunization produced a similar, although clinically mild disease, which appeared only after a latent period equal to that needed for the active induction of disease. These observations and those concerning the nature of parabiotic transfer of this disease are consistent with but do not conclusively prove the concept that active immunization of the cell recipient by transferred antigen may play a role in the transfer phenomenon along with any antibody which may be formed by the transferred cells.

[学科分类] 生物科学（综合）