Differentiation of Cross-Reacting Simian Cytomegalovirus Strains by Late 19S Rabbit Neutralizing Antibodies

[摘要] The results of studies reported previously (1–3) demonstrated heterogeneity in the neutralizing properties of early (7-day) and late (hyperimmune) 7S and 19S antibodies prepared in rabbits against human herpes simplex virus (HSV) and the simian herpesvirus SA8. In the case of the late antibodies, we showed reciprocal cross-neutralization with the 7S antibodies, whereas neutralization by the 19S antibodies was limited essentially to the immunizing virus (3). Recent studies in this laboratory have been concerned with determining antigenic relationships between cytomegalovirus (CMV) strains using late immune rabbit sera (4). Evidence is presented here that the properties of late 7S and 19S rabbit antibodies prepared against simian CMV strains are similar to those reported previously for late 7S and 19S anti-HSV and anti-SA8 antibodies with respect to their specificity for the immunizing virus.Three simian CMV strains were employed. Strain SA6 was isolated from a naturally infected vervet monkey (5), and strains CV-207 and CV-209 were isolated from African green monkeys which had been inoculated with human CMV (6).

[学科分类] 生物科学（综合）