Enhancing Antibody

[摘要] While studying the enhancement of normal skin homografts in rats, we have observed that Lewis (Le)2 antisera created against either Buffalo[2][1] (Bf) or Brown Norway (BN)[3][2] rat tissues prolonged survival of test skin grafts taken from both donor strains. In each case, however, the antiserum prolonged the survival of its specific homograft to a greater degree than the cross-reacting graft. The data presented here indicate that Bf and BN rats share histocompatibility antigens, and that Le anti-Bf enhancing sera contain antibodies to more than one transplantation antigen.The production of enhancing sera and their assay for prolongation of skin homograft survival on 10- to 12-day-old Lewis rats[2][1] [3][2] have been previously described (1). Briefly, 200- to 250-g male rats received first and second set skin grafts followed by two weekly infusions of 20 to 30 × 106 donor spleen cells. One week after the last infusion the serum was harvested. [1]: #fn-2 [2]: #fn-3

[学科分类] 生物科学（综合）