Quantitative Aspects of Influenza Virus Multiplication

[摘要] The multiplication of influenza virus in the cells of the allantois and the resulting increase of virus in the allantoic fluid have been shown repeatedly to be logarithmic (24, 25, 26). This steady exponential increase is presumed to be the result of a succession of multiplication cycles with a constant multiplication factor (“cyclic increment”) and of constant duration (“cycle time”); as the cycles gradually merge into each other the growth process, having been discontinuous in its early stages, becomes approximately logarithmic in its later stages. For the increase of influenza A viruses in the allantoic fluid, the average increment was estimated in Henle's one-step growth experiments (17, 27) to be between 50 and 100. The same experiments showed that liberation of newly formed virus began after a constant period of 5 to 6 hours, although the average time for liberation, namely the time at which half the ultimate first-cycle yield of virus had been liberated, appeared to be about 8 hours.

[学科分类] 生物科学（综合）